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Jatrorrhizine

MCE 国际站：Jatrorrhizine

品牌：MedChemExpress (MCE)

货号：HY-N0749

CAS 号：3621-38-3

生物活性：小檗碱是从黄连中分离得到的一种生物碱，具有神经保护、抗菌、抗疟和抗氧化活性[1]。小檗碱是一种强效的口服乙酰胆碱酯酶（AChE）抑制剂（IC50=872 nM），对丁酰胆碱酯酶（BuChE）的选择性超过115倍[2]。小檗碱通过抑制摄取-2转运蛋白来减少5-羟色胺（5-HT）和去甲肾上腺素（NE）的摄取[3]。

体外研究(In Vitro)：Jatrorrhizine has antiplasmodial and antiamoebic activity, it against Plasmodium falciparum and E. histolytica with IC50 values of 3.15 and 82.7 µM, respectively[1].The hOCT2 (organic cation transporter 2), hOCT3, and PMAT (plasma membrane monoamine transporter) are capable of transporting monoamine neurotransmitters in the brain[3]. Jatrorrhizine has the inhibitory potency of jatrorrhizine on 5-HT and NE uptake in hOCT2-, hOCT3-, and PMAT-transfected cells. Jatrorrhizine strongly inhibits PMAT-mediated MPP+ uptake with an IC50 value of 1.05 μM and reduces 5-HT and NE uptake mediated by hOCT2, hOCT3, and hPMAT with IC50 values of 0.1-1 μM (for OCT2 and OCT3) and 1-10 μM (for PMAT)[3].Clearance of neurotransmitters released into the synaptic cleft is defined by two distinct processes. Uptake-1, the common target of current applied antidepressants, is comprised of the serotonin transporter (SERT), the “SERT”, had a high affinity but low capacity to take up [3H]5-HT. Uptake-2 transporters are an important supplementary regulation system in monoamine clearancethought to be the “NET”, has low affinity but high capacity to take up [3H]5-HT into brain slices. Jatrorrhizine significantly inhibited 5-HT and NE uptake in synaptosomes at 25 μM and 50 μM[3]. MCE尚未独立确认这些方法的准确性。 仅供参考。

体内研究(In Vivo)：Jatrorrhizine (intraperitonealinjection; 5, 10, 20 mg/kg) can significantly reduce the duration of immobility when compared with vehicle control group in tail suspension test (TST)[2]. MCE尚未独立确认这些方法的准确性。 仅供参考。

分子量：338.38

Formula：C20H20NO4+

运输条件：美国大陆地区的室温；其他地区可能有所不同。

储存方式：请按照分析证书中推荐的条件储存产品。

文献引用：MCE 顾客使用本产品发表 3 篇科研文献

提供质量检测报告：Data Sheet、产品使用指南

产品活性：Jatrorrhizine是从黄连中分离得到的生物碱，具有神经保护、抗菌、抗疟原虫和抗氧化活性。Jatrorrhizine是有效的，具有口服活性的乙酰胆碱酯酶 (AChE) (IC50=872 nM) 的抑制剂，是对 BuChE 的选择性为 115 倍。Jatrorrhizine 通过抑制 uptake-2 transporter 的活性减少血清素 (5-HT) 和去甲肾上腺素 (NE) 的摄取。

IC50 & Target：IC50: 872 nM (AChE)[1]

相关产品：Jatrorrhizine chloride  | Isoimperatorin  | Jatrorrhizine hydroxide  | Isoimperatorin (Standard)  | Timosaponin AIII  | Imperatorin  | Jatrorrhizine chloride (Standard)  | Demethoxycurcumin  | Linarin  | Tenuifolin  | Demethoxycurcumin (Standard)  | Timosaponin AIII (Standard)

热门产品线：抑制剂  | 稳定性同位素标记物  |  脂质  |  糖类

Trending products：Inhibitors  | Isotope-Labeled Compounds  |  Lipids  |  Saccharides

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客户发表文献：
[1]. Nature. 2026 Sep;657(8131):549-558.
[2]. Nature. 2026 Sep;657(8132):755-764.
[3]. Nature. 2026 Sep;657(8133):1027-1034.
[4]. Nature. 2026 Sep;657(8131):477-486.
[5].Nature. 2026 Sep;657(8132):789-799.
[6]. Nature. 2026 Sep;657(8131):517-524.
[7]. Nature. 2026 Sep;657(8133):1045-1052.
[8]. Cell. 2026 Sep 14:S0092-8674(26)01003-2.
[9]. Cell. 2026 Sep 3;189(18):5688-5705.e13.
[10]. Cell. 2026 Sep 2:S0092-8674(26)00937-2.

参考文献：
[1]. Sun S, et al. Jatrorrhizine reduces 5-HT and NE uptake via inhibition of uptake-2 transporters and produces antidepressant-like action in mice. Xenobiotica. 2019 Oct;49(10):1237-1243.
[2]. Xiaofei Jiang, et al. Synthesis and Biological Evaluation of Novel Jatrorrhizine Derivatives with Amino Groups Linked at the 3-Position as Inhibitors of Acetylcholinesterase. Research Article Volume 2017
[3]. C W Wright, et al. In vitro antiplasmodial, antiamoebic, and cytotoxic activities of some monomeric isoquinoline alkaloids. J Nat Prod. 2000 Dec;63(12):1638-40.