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ACTH (1-17)

MCE 国际站：ACTH (1-17)

品牌：MedChemExpress (MCE)

货号：HY-P1545

CAS 号：7266-47-9

生物活性： ACTH (1-17) 是一种促肾上腺皮质激素类似物，是强效的人类黑皮质素 1 (MC1) 受体激动剂，其 Ki 值为 0.21 nM。

体外研究(In Vitro)：ACTH (1-17) is a potent agonist at the hMC1R. ACTH (1-17) shows high affinity for the hMC1R with a Ki value of 0.21±0.03 nM which is slightly higher than that of 0.13±0.005 nM for alpha-MSH[1]. ACTH (1-17) induces a slight and not significant increase in growth hormone secretion even when micromolar concentrations of the peptide are employed in rat pituitary cultures[2]. MCE尚未独立确认这些方法的准确性。 仅供参考。

体内研究(In Vivo)：Inhibition of DNA labeling is noted when the ACTH (1-17) is administered at 2 hr after the beginning of the daily dark span when nocturnal animals become active. When administered at this circadian stage, the larger dose in particular is associated with an inhibition of DNA labeling lasting for 24 hr. The inhibitory effect is much shorter when the same dose is injected 4 hr earlier[3]. MCE尚未独立确认这些方法的准确性。 仅供参考。

分子量：2093.41

Formula：C95H145N29O23S

Sequence：Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg

Sequence Shortening：SYSMEHFRWGKPVGKKR

运输条件：美国大陆地区的室温；其他地区可能有所不同。

储存方式：请按照分析证书中推荐的条件储存产品。

Cell Assay [1]：大鼠垂体细胞在不同浓度的 ACTH (1-17) (0.1 nM-1 μM) 存在下孵育。据记录，每个浓度的生长激素分泌量均显着增加[1]。 MCE 尚未独立确认这些方法的准确性。仅供参考。

Animal Administration [3]：Mice[3] The effects of ACTH (1-17) on the rate of DNA labeling in the metaphyseal bone of CD2F1 mice are tested on a chronopharmacological dosing schedule. Groups of mice that has been conditioned to a 12-hr light/12-hr dark schedule are injected at one of six different timepoints, 4 hr apart during ,a single 24-hr span with either a low (0.021 I.U/kg) or a high (20 I.U./kg) dose of ACTH (1-17). Control groups receive injections of a placebo at corresponding timepoints. Subgroups of mice are injected with [3H]thymidine ([3H]Tdr) to follow the changes in DNA labeling in the proximal tibial metaphysis at 15 min and 2, 4, 8, 12 and 24 hr after ACTH (1-17) or placebo treatment[3]. MCE尚未独立确认这些方法的准确性。 仅供参考。

提供质量检测报告：Data Sheet、产品使用指南

产品活性：ACTH (1-17) 是促肾上腺皮质激素类似物，是一种有效的人黑皮素受体 (human melanocortin 1 (MC1) receptor) 激动剂，Ki 值为0.21 nM。

IC50 & Target：Ki: 0.21 nM (human MC1 receptor)[1]

相关产品：β-Melanocyte Stimulating Hormone (MSH), human  | MSG606  | ACTH (11-24)  | Adrenocorticotropic hormone (1-39), rat  | JKC363  | RO27-3225 TFA  | γ-1-Melanocyte Stimulating Hormone (MSH), amide  | Adrenocorticotropic Hormone (ACTH) (1-39), human  | γ1-MSH  | ACTH (22-39)  | Adrenocorticotropic Hormone (ACTH) (4-10), human  | [D-Trp8]-γ-MSH

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客户发表文献：
[1]. Nature. 2026 Sep;657(8131):549-558.
[2]. Nature. 2026 Sep;657(8132):755-764.
[3]. Nature. 2026 Sep;657(8133):1027-1034.
[4]. Nature. 2026 Sep;657(8131):477-486.
[5].Nature. 2026 Sep;657(8132):789-799.
[6]. Nature. 2026 Sep;657(8131):517-524.
[7]. Nature. 2026 Sep;657(8133):1045-1052.
[8]. Cell. 2026 Sep 14:S0092-8674(26)01003-2.
[9]. Cell. 2026 Sep 3;189(18):5688-5705.e13.
[10]. Cell. 2026 Sep 2:S0092-8674(26)00937-2.

参考文献：
[1]. Tsatmali M et al. ACTH1-17 is a more potent agonist at the human MC1 receptor than alpha-MSH. Cell Mol Biol (Noisy-le-grand). 1999 Nov;45(7):1029-34.
[2]. Ceda GP, et al. The effects of ACTH (1-17) on GH secretion in vitro. Horm Metab Res. 1987 Aug;19(8):361-3.
[3]. Walker WV, et al. Effect of an adrenocorticotropin analogue, ACTH (1-17), on DNA synthesis in murine metaphyseal bone. Biochem Pharmacol. 1985 Apr 15;34(8):1191-6.