湖北蝶化新材料科技有限公司

164332-88-1

C9H18BrNO3

中文名称溴-一聚乙二醇-氨基叔丁酯中文同义词叔丁氧羰基-二聚乙二醇-溴代;(2-(2-溴乙氧基)乙基)氨基甲酸叔丁酯;叔丁氧羰基聚乙二醇溴;N-BOC-2-(2-溴乙氧基)乙胺;叔丁氧羰基-PEG1-溴;N-BOC-溴代二聚乙二醇;溴-一聚乙二醇-氨基叔丁酯;BOC-NH-PEG1-CH2CH2BR英文名称Br-PEG1-NHBoc英文同义词t-boc-N-amido-PEG2-bromide;N-Boc-PEG1-bromide;tert-Butyl(2-(2-bromoethoxy)ethyl)carbamate;tert-ButylN-[2-(2-bromoethoxy)ethyl]carbamate;CAS_164332-88-1;t-boc-N-amido-PEG2-bromid;Carbamicacid,N-[2-(2-bromoethoxy)ethyl]-,1,1-dimethylethylester;t-boc-N-amido-PEG1-bromideCAS号164332-88-1分子式C9H18BrNO3分子量268.15EINECS号相关类别其它;助剂Mol文件164332-88-1.mol结构式溴-一聚乙二醇-氨基叔丁酯性质沸点336.6±22.0°C(Predicted)密度1.283±0.06g/cm3(Predicted)储存条Chemicalbook件Sealedindry,Storeinfreezer,under-20°C溶解度溶于水、DMSO、DCM、DMF形态液体酸度系数(pKa)12.19±0.46(Predicted)颜色无色至浅黄溴-一聚乙二醇-氨基叔丁酯用途与合成方法生物活性N-Boc-PEG2-bromide是一种PROTAC连接桥，属于PEG类和Alkyl/ether类。N-Boc-PEG2-bromide可用于合成一系列PROTAC分子。N-Boc-PEG2-bromide是一种可降解(cleavable)的ADC连接桥，用于抗体药物结合物(ADCs)的合成。靶点CleavablePEGsAlkyl/ether体外研究PROTACscontaintwodifferentligandsconnectedbyalinker;oneisaligandforanE3ubiquitinligaseandtheotherisforthetargetprotein.PROTACsexploittheintracellularubiquitin-proteasomesystemtoselectivelydegradetargetproteins.ADCsarecomprisedofanantibodytowhichisattachedanADCcytotoxinthroughanADClinker.