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N,N,N',N'-四(2-吡啶甲基)乙二胺 |
| CAS No.: |
16858-02-9 |
| 分子式： |
C26H28N6 |
| 分子量： |
424.5407 |
| 备注： |
中文名称N,N,N’,N’-四(2-吡啶甲基)乙二胺中文同义词N,N,N’,N’-4(2-吡啶甲基)乙二胺;N,N,N’,N’-四(2-吡啶甲基)乙二胺,室温保存即可;1,2-乙烷二胺,N,N,N’,N’-四(2-吡啶基甲基)-;N,N,N’,N’-四(2-吡啶甲基)乙二胺;N,N,N’,N’-四(2-吡啶甲基)乙二胺;N,N,N’,N’-四-(2-吡啶基甲基)乙二胺;N,N,N’,N’-四KIS-(2-吡啶基甲基)乙二胺;N,N,N’,N’-四-(2-吡啶基甲基)乙二英文名称TPEN英文同义词TETRAKIS-(2-PYRIDYLMETHYL)ETHYLENEDIAMINE;{2-[BIS(PYRIDIN-2-YLMETHYL)AMINO]ETHYL}BIS(PYRIDIN-2-YLMETHYL)AMINE;TPEN-CAS16858-02-9-Calbiochem;N,N,N’,N’-tetrakis(2-pyridinylmethyl)-1,2-Ethanediamine;CS-960;TPEN;1,2-Ethanediamine,N,N,N’,N’-tetrakis(2-pyridinylmethyl)-;1,2-Ethanediamine,N,N,N’,N’-tetrakis(2-pyridinylmethyl)-,(oc-6-11)-CAS号16858-02-9分子式C26H28N6分子量424.54EINECS号相关类别杂环化合物;合成材料中间体;聚合试剂;其它;Apoptosis;Aromatics;ChelatingAgents&Ligands;Heterocycles;Inhibitors;ApoptosisInducersMol文件16858-02-9.mol结构式N,N,N’,N’-四(2-吡啶甲基)乙二胺性质熔点110-112°C沸点530.56°C(roughestimate)密度1.3893(roughestimate)折射率1.4570(estimate)储存条件Sealedindry,2-8°C溶解度溶于DMSO（高达10mg/ml）。形态棕褐色固体酸度系数(pKa)5.19±0.12(Predicted)颜色灰白色或棕褐色BRN4211982稳定性可在-20°C下的DMSO中的溶液储存长达3个月。InChIInChI=1S/C26H28N6/c1-5-13-27-23(9-1)19-31(20-24-10-2-6-14-28-24)17-18-32(21-25-11-3-7-15-29-25)22-26-12-4-8-16-30-26/h1-16H,17-22H2InChIKeyCVRXLMUYFMERMJ-UHFFFAOYSA-NSMILESC(N(CC1=NC=CC=C1)CC1=NC=CC=C1)CN(CC1=NC=CC=C1)CC1=NC=CC=C1CAS数据库16858-02-9(CChemicalbookASDataBaseReference)N,N,N’,N’-四(2-吡啶甲基)乙二胺用途与合成方法生物活性TPEN(TPEDA)是一种可透过细胞的重金属螯合剂，可通过负调控细胞内NO和Zn2+信号转导来诱导NB4细胞凋亡。TPEN（TPEDA）可能是APL(acutepromyelocyticleukemia)的潜在治疗策略之一。靶点TargetValueNO()体外研究HeavymetalchelatorTPENattenuatesfura-2fluorescencechangesinducedbycadmium,mercuryandmethylmercury.TPEN,acell-permeablechelatorforheavymetalcationswithalowaffinityforCa2+.Incellsstimulatedwith10or30μMcadmiumchloride,theadditionofTPENat3hrafterexposuresignificantlydecreasestheelevatedfura-2fluorescenceratiotothebasallevelswithin10min(119.6±2.4%or109±1.5%decreaseinΔRatio(F340/F380)inducedby10or30μMcadmiumchloride,respectively),suggestingthatacadmiumchloride-inducedincreaseinthefura-2fluorescenceratioisdependentonanincreaseinintracellularheavymetalcationsbutnotintracellularCa2+.TPENisametalchelator,whichtargetscoloncancercellsthroughredoxcyclingofcopper.TPENreducescellviabilityinadose-andtime-dependentmanner.TPEN-inducedcelldeathisalsodependentontheredoxcyclingofcoppersincethecopperchelatorneocuproineinhibitedDNAdamageandreducedpChk1,γ-H2AX,andATMproteinexpression.CelldeathbylowTPENconcentrations,involvedATM/ATRsignalinginall3celllines,sincepre-incubationwithspecificinhibitorsofATMandDNA-PKledtotherecoveryofcellsfromTPEN-inducedDNAdamage. |
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